p53 deficiency augments nucleolar instability after ionizing irradiation
نویسندگان
چکیده
منابع مشابه
Thyroid cancer after external or internal ionizing irradiation.
It has been known for 50 years that thyroid exposure to high doses of ionizing radiation in childhood and adolescence induces an appreciable cancer risk. Epidemiological studies in children treated with external radiotherapy for benign or malignant lesions in the head and neck have also shown the induction of thyroid cancer. The World Health Organization (WHO) has reported that the risk for dev...
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The function of the p53 tumor suppressor protein must be highly regulated because p53 can cause cell death and prevent tumorigenesis. In cultured cells, the p90MDM2 protein blocks the transcriptional activation domain of p53 and also stimulates the degradation of p53. Here we provide the first conclusive demonstration that p90MDM2 constitutively regulates p53 activity in homeostatic tissues. Mi...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2019
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.2019.7341